New location for hypermutation
نویسندگان
چکیده
منابع مشابه
A New Model for Location-Allocation Problem within Queuing Framework
This paper proposes a bi-objective model for the facility location problem under a congestion system. The idea of the model is motivated by applications of locating servers in bank automated teller machines (ATMS), communication networks, and so on. This model can be specifically considered for situations in which fixed service facilities are congested by stochastic demand within queueing frame...
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هدف اصلی از این تحقیق به دست آوردن و مقایسه حق بیمه باورمندی در مدل های شمارشی گزارش نشده برای داده های طولی می باشد. در این تحقیق حق بیمه های پبش گویی بر اساس توابع ضرر مربع خطا و نمایی محاسبه شده و با هم مقایسه می شود. تمایل به گرفتن پاداش و جایزه یکی از دلایل مهم برای گزارش ندادن تصادفات می باشد و افراد برای استفاده از تخفیف اغلب از گزارش تصادفات با هزینه پائین خودداری می کنند، در این تحقیق ...
15 صفحه اولa new model for location-allocation problem within queuing framework
this paper proposes a bi-objective model for the facility location problem under a congestion system. the idea of the model is motivated by applications of locating servers in bank automated teller machines (atms), communication networks, and so on. this model can be specifically considered for situations in which fixed service facilities are congested by stochastic demand within queueing frame...
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Recently the concept of facility efficiency, which defined by data envelopment analysis (DEA), introduced as a location modeling objective, that provides facilities location’s effect on their performance in serving demands. By combining the DEA models with the location problem, two types of “efficiencies” are optimized: spatial efficiency which measured by finding the least cost location and al...
متن کاملEvolution of new nonantibody proteins via iterative somatic hypermutation.
B lymphocytes use somatic hypermutation (SHM) to optimize immunoglobulins. Although SHM can rescue single point mutations deliberately introduced into nonimmunoglobulin genes, such experiments do not show whether SHM can efficiently evolve challenging novel phenotypes requiring multiple unforeseeable mutations in nonantibody proteins. We have now iterated SHM over 23 rounds of fluorescence-acti...
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ژورنال
عنوان ژورنال: Nature Reviews Immunology
سال: 2002
ISSN: 1474-1733,1474-1741
DOI: 10.1038/nri923